Use of Neoadjuvant Chemotherapy (NACT)

Neoadjuvant therapy refers to a therapy administered before the main treatment (usually surgery) is given.

Neoadjuvant cisplatin-containing combination chemotherapy increases the length of time from start of treatment to death. Cisplatin is a drug that interferes with DNA replication and hence cancer cell growth.

Performance status is an attempt to quantify cancer patients general well being. Neoadjuvant chemotherapy is not recommended in patients with poor performance status and/or impaired kidney function.

Although there is no evidence to suggest that the newer chemotherapy regimens are as effective as the older regimens when used in the neoadjuvant setting, the newer chemotherapy regimens have fewer toxic effects and can be used.