Systemic Chemotherapy Strategies in Patients with Metastatic Colorectal Cancer

Metastatic colorectal cancer refers to colorectal cancer that has spread to other sites in the body.

Some cancer cells have proteins on their surface called epidermal growth factor receptors (EGFRs). Some drugs known as EGFR inhibitors such as cetuximab inhibit the function of these proteins, preventing them from promoting growth of cancer cells.

Cetuximab should be used with caution in patients with colorectal cancer that can be treated by surgically removing the tumour, as it reduces the amount of time that passes from the first day of treatment to the day on which the disease is found to have worsened.