What is the Role of Chemotherapy Following Surgery in Women Diagnosed with Endometrial Cancer?

Chemotherapy in the adjuvant setting is given together with another treatment (like surgery) to increase its effectiveness.

Adjuvant chemotherapy should be offered to patients with endometrial cancer stage 3 and 4. It can also be offered to women with stage 1B/2, grade 3 cancer and adverse risk factors. This is because they have a higher risk of cancer relapse beyond the pelvis and have possible benefit from chemotherapy.

For adjuvant chemotherapy, carboplatin and paclitaxel taken 3 weekly for 4-6 cycles are recommended.

Carboplatin is a drug used to treat cancer cells by disrupting cell growth of cancer cells. Paclitaxel belongs to the taxane family of drugs that inhibit cancer growth.