What is the Role of Chemotherapy in Women with Uterine Papillary Serous Carcinoma (UPSC) or Clear Cell Carcinoma?

Chemotherapy should be recommended for patients with all stages of UPSC/clear cell carcinoma, including those with stage 1 disease.

It should be considered for women with cancers of:

Stage 1A without spreading of cancer into the middle layer of the uterus lining known as the myometrium

Stage 1A with spreading of cancer into the middle layer of the uterus lining known as the myometrium

Stages 1B to 4

Platinum-based chemotherapy consisting of multiple drugs can be used if the patient is able to tolerate the side effects.