Who should be referred for Hereditary Breast and Ovarian Cancer Syndrome?

Having a personal history of a disease means to have had that disease before. Having a family history of a disease means to have family members with that disease.

Patients with the following should be referred for genetic testing for hereditary breast and ovarian cancer syndrome:

Personal or family history of breast cancer diagnosed <40 years of age;

Personal or family history of male breast cancer, any age;

Personal or family history of epithelial ovarian cancer, any age;

Personal or family history of triple negative breast cancer diagnosed <50 years of age

Family with 2 or more breast cancers, at least one aged <50 years of age;

Family with both breast and epithelial ovarian cancers;

Two or more tumours (breast cancer affecting both breasts; multiple breast cancers; breast and ovarian cancer);

Family with known genetic change or mutation in the BRCA1/21 gene