What is the Role of Adjuvant Chemotherapy in Stage I?

Chemotherapy in the adjuvant setting is given together with another treatment (like surgery) to increase its effectiveness.

These are the recommended guidelines according to the stage of the cancer and surgical margins.

T stage

T stage describes the size of the original tumour. A higher T stage corresponds to bigger size.

Has the cancer spread to the lymph nodes?

Lymph nodes are small organs that are part of the lymphatic system, a system in the body that transports a type of fluid called lymph throughout the body.

Are cancer cells found in the tissue surrounding the tumour after surgery?

Recommendation

T1ab

No

No

Observation, meaning active monitoring of disease without treatment.

T2ab

No

No

Observation, meaning active monitoring of disease without treatment.

Chemotherapy is recommended for patients with high risk features - for example, tumours with cancer cells that have abnormal characteristics, spreading of the cancer into blood vessels, surgical removal of a wedge of cancerous tissue, tumour of size >4 cm, spreading of the cancer to the membrane covering the lung known as the visceral pleura, and incomplete surgical removal of lymph nodes for analysis.

Lymph nodes are small organs that are part of the lymphatic system, a system in the body that transports a type of fluid called lymph throughout the body.