Adjuvant Therapy for Patients Post-surgery

The following recommendations apply to patients with pancreatic adenocarcinoma who have undergone surgical removal of tumour. Adjuvant chemotherapy refers to drugs given after complete surgery to reduce the chance of cancer relapse.

A scan to redetermine the stage of the cancer should be performed prior to start of chemotherapy to rule out any spreading of the cancer to other sites in the body.

Treatment with gemcitabine ortegafur-gimeracil-oteracil potassium(TS-1) are both reasonable options after surgical removal of tumours in pancreatic adenocarcinoma with cancer cells that have spread to different sites in the body. Gemcitabine and TS-1 are anti-cancer chemotherapy drugs.

After surgical removal of tumours in pancreatic adenocarcinoma with cancer cells that have spread to different sites in the body, additional treatment using radiation given together with chemotherapy treatment is not recommended unless there are cancer cells found in the margin of the surgically removed tumor. These chemotherapy drugs, commonly known as fluoropyrimidines, are used to reduce growth of cancer by interfering with genetic replication of rapidly-dividing cancer cells.