What are recommendations for first-line palliative chemotherapy for osteosarcoma?

Methotrexate given in high doses, doxorubicin and cisplatin are recommended for children and young adults with good kidney function. Methotrexate interferes with cell growth by inhibiting DNA, RNA and protein synthesis and targets cancer cells as they are actively producing DNA and RNA. Adriamycin (also known as doxorubicin) interacts with DNA and inhibits protein synthesis, hence inhibiting cancer cell growth. Cisplatin is a drug that interferes with DNA replication and hence cancer cell growth.

Doxorubicin and cisplatin are recommended for older adults.