What are recommendations for second-line palliative chemotherapy for osteosarcoma?

Recommendations are as follows:

1.Ifosamide and etoposide. Ifosfamide is an anticancer alkylating agent that makes DNA stick together so the cell cannot grow. Etoposide is an anticancer drug that causes DNA strands to break and promotes death of cancer cells.

2.Gemcitabine and docetaxel. Gemcitabine is a drug that inhibits cancer cell growth and promotes cancer cell death. Docetaxel is an anti-cancer drug that inhibits cancer cell division.

3.Gemcitabine, a drug that inhibits cancer cell growth and promotes cancer cell death.